New release 2019/06/24
Polymer synthesis method of N – isopropylacrylamide (AIBN)
1 N – isopropylacrylamide Commercial product was recrystallized from benzene / n – hexane solvent and dried under reduced pressure.
2 Azobisisobutyronitrile (AIBN) was commercially available by recrystallization from methanol and drying under reduced pressure.
3 Commercial products were used for hydroquinone and others
4 Purify NIPAM (about 120 g) and polymerization initiator AIBN (about 0.35 g) with about 500 ml methanol.
5 Incubate nitrogen gas for about 1 hour, then raise it to 50 degrees c and expand sales for about 2 hours.
6 Hydroquinone 0.3 g is added to terminate the polymerization.
7 Inflow into warm water (about 31 ° C or higher).
8 The precipitate is recovered and dried on a hot plate to obtain a film-like polymer.
Poly N – isopropylacrylamide ( PIPAAm )
Poly(N-isopropylacrylamide) (variously abbreviated PNIPA, PNIPAAm, PNIPAA or PNIPAm) is a temperature-responsive polymer that was first synthesized in the 1950s. It forms a three-dimensional hydrogel when crosslinked with N,N’-methylene-bis-acrylamide (MBAm) or N,N’-cystamine-bis-acrylamide (CBAm). When heated in water above 33°C, it undergoes a reversible lower critical solution temperature phase transition from a swollen hydrated state to a shrunken dehydrated state, losing about 90% of its mass. Since PNIPAm expels its liquid contents at a temperature near that of the human body, PNIPAm has been investigated by many researchers for possible applications in controlled drug delivery.
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